thefreevariable replied: "Antidepressants can lose their effectiveness, but not always. The most troublesome aspect of antidepressants is that they take so long to work and each one has a very different effectiveness on different people.
As for amphetamines, I know a case where a patient with both depression and ADHD was given a new stimulant for the ADHD and it improved his depression. Unfortunately, while the medication's effect on ADHD persisted, the depression returned in full force within two weeks. So I'm not convinced that stimulants are the answer.
Interestingly, that patient improved greatly on a dopamine agonist indicated for Parkinson's. The point is that there is not currently a "best" treatment; it's just whatever works best for the individual.
And of course any pharmacological treatment can (and should, according to studies) be augmented by some form of therapy. This increases the effectiveness of the treatment overall."
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